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Identification of new partner chromosomes involved in fusions with the ETV6 (TEL) gene in hematologic malignancies
Author(s) -
Tosi Sabrina,
Giudici Giovanni,
Mosna Giuliana,
Harbott Jochen,
Specchia Giorgina,
Grosveld Gerard,
Privitera Enrica,
Kearney Lyndal,
Biondi Andrea,
Cazzaniga Giovanni
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199803)21:3<223::aid-gcc6>3.0.co;2-1
Subject(s) - etv6 , chromosomal translocation , biology , gene , genetics , breakpoint , fusion gene , chromosome , myeloid , karyotype , chromosome 15 , cancer research
Several partner genes on different chromosomes have been reported to be fused with the ETV6 gene (located in chromosome band 12p13), with different breakpoints and different frequencies, in various hematologic malignancies, particularly acute myeloid and lymphoid leukemias and myelodysplastic syndromes. By using FISH and molecular analyses, we have analyzed five different pediatric and adult patients carrying cytogenetic abnormalities involving 12p13. Our findings demonstrate that ETV6 was rearranged in all the cases analyzed. In particular, ETV6 was disrupted by translocations with chromosomal bands 7q22, 7q36, 9q11, and 13q12, not previously described as partners of ETV6 in translocations, thus extending its promiscuity in rearranging with different partner genes. Genes Chromosomes Cancer 21:223–229, 1998. © 1998 Wiley‐Liss, Inc.