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Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade
Author(s) -
Mohapatra Gayatry,
Bollen Andrew W.,
Kim Dong H.,
Lamborn Kathleen,
Moore Dan H.,
Prados Michael D.,
Feuerstein Burt G.
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199803)21:3<195::aid-gcc3>3.0.co;2-v
Subject(s) - glioblastoma , comparative genomic hybridization , epidermal growth factor receptor , biology , chromosome , cancer research , oncology , cancer , genetics , medicine , gene
We analyzed 72 primary and 25 recurrent glioblastoma multiforme (GBM) samples for DNA sequence copy number abnormalities (CNAs) by comparative genomic hybridization (CGH). The number of aberrations per tumor ranged from 2 to 23 in primary GBM and 5 to 25 in recurrent GBM. There were 26 chromosome regions with CNAs in more than 20% of tumors. 7q22‐36 was the most common gain and 10q25‐26 was the most common loss; each occurred in more than 70% of tumors. Of 27 amplification sites, epidermal growth factor receptor (EGFR) was the most common; it was observed in 25% of primary GBMs. Statistical analysis based on pairwise correlation of CNAs indicated that there is more than one class of primary GBM. Genes Chromosomes Cancer 21:195–206, 1998. © 1998 Wiley‐Liss, Inc.