Premium
Mapping of a new target region of allelic loss to a 2‐cM interval at 22q13.1 in primary breast cancer
Author(s) -
Iida Aritoshi,
Kurose Keisuke,
Isobe Rie,
Akiyama Futoshi,
Sakamoto Goi,
Yoshimoto Masataka,
Kasumi Fujio,
Nakamura Yusuke,
Emi Mitsuru
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199802)21:2<108::aid-gcc5>3.0.co;2-4
Subject(s) - loss of heterozygosity , locus (genetics) , biology , allele , deletion mapping , breast cancer , cancer research , chromosome , deleted in colorectal cancer , chromosome 17 (human) , genetics , gene , pathology , cancer , colorectal cancer , medicine
Allelic losses on chromosome arm 22q are frequently observed in human meningiomas and in carcinomas of the colon, ovary, and breast. Among 140 primary breast cancers we examined for loss of heterozygosity (LOH) at 16 polymorphic loci on the long arm of chromosome 22, 56 (40%) showed LOH for at least one locus. Eleven of these tumors had retained heterozygosity for markers proximal to the NF2 locus but showed LOH for markers distal to NF2. Deletion mapping indicated a new common region of deletion, 2‐cM in extent, at q13.1 between Interleukin 2 receptor β ( IL2RB ) and D22S279. Our results raise the possibility that one or more tumor suppressor genes associated with breast cancer may exist at 22q13.1. Comparison of these results with clinicohistological data indicated that allelic losses on 22q tend to occur more frequently in tumors of malignant histological types. Genes Chromosomes Cancer 21:108–112, 1998. © 1998 Wiley‐Liss, Inc.