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Location of the BCR ‐ ABL fusion gene on the 9q34 band in two cases of Ph‐positive chronic myeloid leukemia
Author(s) -
Aurich Joan,
Dastugue Nicole,
Duchayne Eliane,
Schlaifer Daniel,
RigalHuguet Françoise,
Caballin M. Rosa
Publication year - 1997
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199710)20:2<148::aid-gcc5>3.0.co;2-3
Subject(s) - fusion gene , chromosomal translocation , abl , myeloid leukemia , breakpoint cluster region , cancer research , gene , biology , leukemia , derivative chromosome , cancer , genetics , microbiology and biotechnology , chromosome 22 , tyrosine kinase , signal transduction
Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR ‐ ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;q11), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretation of cytogenetic, FISH, and molecular data. The mechanisms of the two rearrangements are presented. It is suggested that the insertion has occurred in a single event in the patient with ins(9;22). In the patient with t(9;22), both a translocation and an insertion, occurring either sequentially or simultaneously, can account for the location of the BCR ‐ ABL fusion gene on the derivative 9. A possible poor prognostic impact of this aberrant location of the BCR ‐ ABL is also suggested by the clinical data reported in such patients. Genes Chromosomes Cancer 20:148–154, 1997. © 1997 Wiley‐Liss, Inc.