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The first recurring chromosome translocation in hepatoblastoma: Der(4)t(1;4)(q12;q34)
Author(s) -
Schneider Nancy R.,
Cooley Linda D.,
Finegold Milton J.,
Douglass Edwin C.,
Tomlinson Gail E.
Publication year - 1997
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199708)19:4<291::aid-gcc13>3.0.co;2-j
Subject(s) - hepatoblastoma , chromosomal translocation , biology , genetics , medicine , gene
We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q12;q34), whereas the fourth case appeared to have a der(4)t (q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene or genes on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin. Genes Chromosom. Cancer 19:291–294, 1997. © 1997 Wiley‐Liss, Inc.