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Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation
Author(s) -
Heinen Christopher D.,
Noffsinger Amy E.,
Belli Jenine,
Straughen Joel,
Fischer Josef,
Groden Joanna,
FenoglioPreiser Cecilia M.
Publication year - 1997
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199707)19:3<170::aid-gcc6>3.0.co;2-v
Subject(s) - ulcerative colitis , microsatellite , mutation , medicine , genetics , biology , pathology , disease , gene , allele
An increased risk of colon cancer has been observed in individuals with long‐standing ulcerative colitis (UC). In order to identify molecular genetic markers for the development of neoplasia in UC individuals, we isolated DNA from normal, regenerative, and dysplastic mucosa, as well as from colon carcinomas from UC patients, and evaluated it for the presence of mutations in microsatellite DNA sequences. DNAs isolated from regenerative mucosa displayed microsatellite mutation. These observations suggest that DNA mutation is an early event in the UC disease process. Genes Chromosom. Cancer 19:170–175, 1997. © 1997 Wiley‐Liss Inc.