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Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma‐derived cell lines
Author(s) -
Vanni Roberta,
Marras Susanna,
Schoenmakers Eric F. P. M.,
Cin Paola Dal,
Kazmierczak Bernd,
Senger Gabriele,
Bullerdiek Jörn,
Van de Ven Wim J. M.,
Van den Berghe Herman
Publication year - 1997
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199703)18:3<155::aid-gcc1>3.0.co;2-0
Subject(s) - uterine leiomyoma , biology , fluorescence in situ hybridization , cytogenetics , microbiology and biotechnology , genetics , chromosome , gene , pathology , uterus , medicine
Uterine leiomyoma cytogenetically exhibits at least six chromosomally abnormal subgroups. The largest subgroup is characterized by deletions of the long arm of chromosome 7. Few molecular and fluorescence in situ hybridization data are available that have aimed at a better definition of the lesion. Here, we report the results of a partial molecular cytogenetic characterization of two del(7q) chromosomes that were derived from cell lines established from two uterine leiomyomas with del(7)(q22q32). By using a large series of ordered 7q markers, we were able to identify the most proximal and the most distal conserved markers, which delineate the size of the deletion and which allow for a more targeted approach to the nature and function of genes that are possibly relevant for the pathogenesis of the disorder. Genes Chromosom. Cancer 18:155–161, 1997. © 1997 Wiley‐Liss, Inc.