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Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer
Author(s) -
Komiya Akira,
Suzuki Hiroyoshi,
Ueda Takeshi,
Yatani Ryuichi,
Emi Mitsuru,
Ito Haruo,
Shimazaki Jun
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199612)17:4<245::aid-gcc6>3.0.co;2-3
Subject(s) - loss of heterozygosity , prostate cancer , biology , chromosome , allele , metastasis , cancer research , cancer , tumor suppressor gene , chromosome 17 (human) , prostate , stage (stratigraphy) , pathology , chromosome 9 , genetics , primary tumor , gene , carcinogenesis , medicine , paleontology
DNA samples from tumors and paired normal tissues from 48 patients with prostate cancer (stage B, 16 cases; stage C, 14 cases; stage D, 18 cases) were examined with 26 polymorphic markers spanning chromosome 10. Allelic losses were observed in 17 of the 46 cases (37%) that were informative with at least one of the markers. Detailed deletion mapping identified two distict commonly deleted regions on the long arm of chromosome 10 (10q22–q24:7cM and 10q25.1:17cM) and one on 10p, suggesting that at least three tumor suppressor genes associated with prostate cancer are present on this chromosome. We observed loss of heterozygosity more frequently in tumors from fatal cases (stage D, 8/16, 50%) than in localized tumors (stage B, 0/16, 0%; P = 0.001 or stage B + C, 5/30, 17%; P = 0.02 Fisher's exact test). All metastatic tissues showed allelic loss at one or more loci on 10q. In five of the nine patients from whom DNAs were available from both metastatic and primary tumors, the primary cancer foci had no detectable abnormality of chromosome 10, while the metastatic foci showed allelic loss on chromosome 10. These results suggested that inactivation of one or more tumor suppressor genes on chromosome 10 plays an important role in late stages of prostate cancer. Genes Chromosom Cancer 17:245–253 (1996). © 1996 Wiley‐Liss, Inc.