Premium
Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families
Author(s) -
Petersson Catarina,
Pandis Nikos,
Mertens Fredrik,
Adeyinka Adewale,
Ingvar Christian,
Ringberg Anita,
Idvall Ingrid,
Bondeson Lennart,
Borg Åke,
Olsson Håkan,
Kristoffersson Ulf,
Mitelman Felix
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199607)16:3<185::aid-gcc5>3.0.co;2-v
Subject(s) - breakpoint , breast cancer , carcinogenesis , chromosome , genetics , biology , cancer , medicine , gene
Short‐term cultures of samples from eight prophylactic mastectomies from five unrelated women who where genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1 q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored. Genes Chromosom Cancer 16:185–188 (1996). © 1996 Wiley‐Liss, Inc.