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Cohabiting t(12;22) and inv(3) primary rearrangements in an acute myelomonocytic leukemia (FAB M4) cell line
Author(s) -
MacLeod Roderick A. F.,
Hu ZhenBo,
Kaufmann Maren,
Drexler Hans G.
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199606)16:2<144::aid-gcc9>3.0.co;2-#
Subject(s) - ataxia telangiectasia , acute myelomonocytic leukemia , chromosomal translocation , breakpoint , myeloid leukemia , leukemia , myeloid , biology , cytogenetics , immunology , genetics , medicine , microbiology and biotechnology , cancer research , chromosome , gene , dna , dna damage
We describe the cytogenetic characterization of MUTZ‐3, the first continuous cell line to be established from acute myelomonocytic leukemia (FAB M4) cells, exhibiting recurrent chromosomal rearrangements associated with this disease category. MUTZ‐3 was established from peripheral blood taken at presentation from a 29‐year‐old male patient and carries the t(12;22)(p13.2;q11.2) associated with acute myelomonocytic leukemia (AMMoL), the inv(3)(q21.2q26.3) associated with multilineage acute myeloid leukemias (AML), and the inv(7)(p14q35) associated with ataxia telangiectasia (A‐T). There was no evidence that the patient was an A‐T heterozygote. The breakpoint on chromosome 22 mapped between 5'BCR and D22S39, consistent with the G‐banding assignment. Both inversions were translocation‐associated and may be further examples of an association previously described in AML FAB M4eo with inv(16). We suggest that the combination of inv(3)/t(3;3) with t(12;22) may represent a new, nonrandom association in AML. Genes Chromosom Cancer 16:144–148 (1996) . © 1996 Wiley‐Liss, Inc.