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Different cytogenetic patterns in skeletal breast cancer metastases
Author(s) -
Adeyinka Adewale,
Pandis Nikos,
Nilsson Johan,
Idvall Ingrid,
Mertens Fredrik,
Petersson Catarina,
Heim Sverre,
Mitelman Felix
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199605)16:1<72::aid-gcc11>3.0.co;2-n
Subject(s) - karyotype , breast cancer , metastasis , cancer , cytogenetics , pathology , biology , oncology , cancer research , metastatic breast cancer , medicine , chromosome , genetics , gene
Short‐term cultures of breast cancer metastases to bone from two patients were analyzed cytogenetically. One metastasis had a complex hypotriploid karyotype with numerous marker chromosomes, whereas the other had simple karyotypic changes in three unrelated clones, 46,XX, t(4;11)(p14;p13)/45,XX,‐19/46,XX,del(3)(p13p23), suggesting that the metastasis had originated from a simultaneous invasion of multiple cells from the primary tumor. The metastasis with complex chromosomal aberrations developed quickly as part of a clinically aggressive disease, whereas that with simple changes developed more than 20 years after the initial breast cancer diagnosis. Our findings therefore indicate that the tumor karyotype may play a role in determining the clinical course in patients with breast cancer. Genes Chromosom Cancer 16:72–74 (1996). © 1996 Wiley‐Liss, Inc.