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Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia
Author(s) -
Soenen Valérie,
Chaffanet Max,
Preudhomme Claude,
Dib Amel,
Laï JeanLuc,
Fletcher Jonathan A.,
Birnbaum Daniel,
Pébusque MarieJosèphe
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199603)15:3<191::aid-gcc9>3.0.co;2-y
Subject(s) - chromosomal translocation , breakpoint , fluorescence in situ hybridization , biology , fish <actinopterygii> , chromosome , acute monocytic leukemia , yeast artificial chromosome , genetics , leukemia , microbiology and biotechnology , gene mapping , gene , fishery
Using a series of yeast artificial chromosomes (YAC) from the 8p11‐12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases. Genes Chromosom Cancer 15:191–194 (1996). © 1996 Wiley‐Liss, Inc.