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Clonal chromosome abnormalities in two chemodectomas
Author(s) -
Jin Yuesheng,
Mertens Fredrik,
Jin Charlotte,
Wennerberg Johan,
Mandahl Nils,
Heim Sverre,
Mitelman Felix
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199603)15:3<178::aid-gcc6>3.0.co;2-#
Subject(s) - chromosome , biology , genetics , gene
Short‐term cultures from two histologically benign chemodectomas, one from the carotid body and one from the vagal nerve, were analyzed cytogenetically. The former had a small abnormal clone with the karyotype 46,XX,t(3;19)(q21;q13),t(12;15) (p13;q12–14), whereas the majority of the cells from the latter tumor displayed two related abnormal clones: 46,XY, i(l)(q10)/46, idem,add(2)(q37). The findings add to the evidence that chemodectomas are heterogeneous neoplasms and suggest that the heterogeneity may possibly be associated with the site of origin. Genes Chromosom Cancer 15:178–181 (1996). © 1996 Wiley‐Liss, Inc.