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Transcriptional control in myelinating glia: The basic recipe
Author(s) -
Wegner Michael
Publication year - 2000
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/(sici)1098-1136(20000115)29:2<118::aid-glia4>3.0.co;2-q
Subject(s) - biology , oligodendrocyte , transcription factor , homeobox , myelin , transcription (linguistics) , zinc finger , regulation of gene expression , gene expression , neuroscience , gene , computational biology , microbiology and biotechnology , genetics , central nervous system , linguistics , philosophy
Development of myelinating glia and the myelination process both require dramatic changes in the pattern of gene expression. During these processes, cells of the oligodendrocyte and Schwann cell lineages have to alter the transcription rates of numerous genes in a highly coordinated manner. This is made possible by the combined action of a set of transcription factors with preferential expression in these cells. Recent years have seen the identification of such glial transcription factors, including several homeodomain proteins, zinc finger proteins and HMG‐domain proteins. Understanding their mode of action will help to unravel the molecular basis of myelination and will provide insights into the causes of myelinopathies and related diseases. GLIA 29:118–123, 2000. © 2000 Wiley‐Liss, Inc.