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Activation of microglial and endothelial cells in the rat brain after treatment with interferon‐gamma in vivo
Author(s) -
Grau Veronika,
Herbst Birgit,
Van der Meide Peter H.,
Steiniger Birte
Publication year - 1997
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/(sici)1098-1136(199703)19:3<181::aid-glia1>3.0.co;2-2
Subject(s) - microglia , biology , in vivo , major histocompatibility complex , immunology , interferon gamma , mhc class ii , microbiology and biotechnology , antigen , neuroglia , cytokine , mhc class i , neuroscience , central nervous system , inflammation
Activation of microglial cells occurs during the pathogenesis of various neurologic diseases. However, the mechanisms of activation in vivo are still elusive. We infused adult rats intravenously with interferon‐γ and demonstrated microglial cell activation after three days of treatment. We show for the first time that microglial cells proliferate inside the brain in response to a circulating cytokine. Microglial cells were induced to express major histocompatibility (MHC) class I and class II antigens and small amounts of leukocyte function‐associated molecule 1 (LFA‐1, CD11a). On endothelial cells of the brain, MHC class I and class II antigens and intercellular adhesion molecule 1 (ICAM‐1, CD54) were enhanced. GLIA 19:181–189, 1997. © 1997 Wiley‐Liss, Inc.