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Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration
Author(s) -
Milner Richard,
Anderson Helen J.,
Rippon Rebecca F.,
McKay Jennifer S.,
Franklin Robin J.M.,
Marchionni Mark A.,
Reynolds Richard,
FfrenchConstant Charles
Publication year - 1997
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/(sici)1098-1136(199701)19:1<85::aid-glia9>3.0.co;2-9
Subject(s) - platelet derived growth factor receptor , oligodendrocyte , platelet derived growth factor , basic fibroblast growth factor , biology , growth factor , precursor cell , fibroblast growth factor , microbiology and biotechnology , neuroglia , receptor , endocrinology , cell , biochemistry , central nervous system , myelin
We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor‐2 (GGF‐2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF‐2 had no effect. The migration‐enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF‐2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development. GLIA 19:85–90, 1997. © 1997 Wiley‐Liss, Inc.