Premium
A reappraisal of ganglioside G D3 expression in the CNS
Author(s) -
Goldman James E.,
Reynolds Richard
Publication year - 1996
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/(sici)1098-1136(199604)16:4<291::aid-glia1>3.0.co;2-3
Subject(s) - biology , ganglioside , neuroscience , expression (computer science) , central nervous system , computational biology , biochemistry , computer science , programming language
G D3 ganglioside is a major glycolipid component of the developing central nervous system but diminishes considerably as the CNS matures. Despite consistent biochemical data, the cellular localization of G D3 expression has been controversial. In this commentary we will review the cellular expression of G D3 during CNS development and in neuropathological circumstances as determined by studies with the two most commonly used anti G D3 monoclonal antibodies, R24 and LB1. G D3 is not restricted to any one cell lineage, being expressed in development to varying degrees by immature neuroectodermal cells, oligodendrocyte progenitors, ameboid microglia, and subpopulations of developing neurons and astrocytes. In the adult CNS, G D3 is expressed in low amounts by some neuronal subpopulations, on reactive and resting microglia, and by reactive astrocytes. In the appropriate contexts of development or neuropathology, anti‐G D3 antibodies are useful for cell type identification and for cell isolation, but caution should be exercised because of the lack of cellular specificity. © 1996 Wiley‐Liss, Inc.