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High Throughput Gene Expression Screening: Its Emerging Role in Drug Discovery
Author(s) -
Freeman Tom
Publication year - 2000
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/(sici)1098-1128(200005)20:3<197::aid-med3>3.0.co;2-1
Subject(s) - drug discovery , computational biology , biology , gene , disease , gene expression , drug , function (biology) , genetics , bioinformatics , pharmacology , medicine
The genetic makeup and the environment influences the health and welfare of an individual. At both the tissue and cellular level, physiological function can be correlated with the transcription of genes, whose protein products contribute and influence the activity of biological systems. In order to understand these processes, it is therefore essential to determine the temporal and spatial patterns of gene expression, and, with particular relevance to drug discovery, define changes that occur during development of disease or treatment with therapeutic agents. © 2000 John Wiley & Sons, Inc., Med Res Rev 20, No. 3, 197–202, 2000