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Multiple drug resistance
Author(s) -
Mitscher Lester A.,
Pillai Segaran P.,
Gentry Elmer J.,
Shankel Delbert M.
Publication year - 1999
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/(sici)1098-1128(199911)19:6<477::aid-med2>3.0.co;2-w
Subject(s) - drug , drug resistance , intensive care medicine , medicine , pharmacology , risk analysis (engineering) , biology , microbiology and biotechnology
Multiple drug resistance to antibacterial agents, antifungals, antivirals, antiprotozoals, and antitumor agents has risen spectacularly in the last decade or so and presently threatens eventually to put an end to successful chemotherapy in all of the above fields. This review summarizes the known origins of the problem, its present dimensions, the means employed to combat the phenomenon and promising avenues for future developments. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 6, 477–496, 1999