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Optimization of solid supports for combinatorial chemical synthesis
Author(s) -
Mendonca Aubrey J.,
Xiao XiaoYi
Publication year - 1999
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/(sici)1098-1128(199909)19:5<451::aid-med10>3.0.co;2-b
Subject(s) - solid phase synthesis , combinatorial chemistry , molecule , combinatorial synthesis , sorting , peptide synthesis , phase (matter) , oligonucleotide , computer science , materials science , chemistry , nanotechnology , peptide , organic chemistry , algorithm , dna , biochemistry
Until recently, resins were used primarily for peptide and oligonucleotide synthesis. Recent advances in combinatorial chemistry have fostered increased acceptance of resins as supports for the synthesis of small molecule libraries. The methodology for selecting a resin bead that is ideal for the solid phase synthesis of small molecules is described in this review. The process of manufacturing a typical resin, the UniSphere ®‐200, is also explained. Furthermore, a new approach is proposed for the solid phase synthesis of analogs which are traditionally done in solution phase. This new procedure involves the use of building blocks attached to an activated resin. These building blocks are displaced by a functional group on the scaffold around which the analogs are built. Use of an excess of resin‐linked building blocks drives the reaction to completion. Additionally, a newly developed, grafted surface solid support, is described. This support, the MicroTube ,® can be used for the synthesis of large numbers of discrete molecules by a patented directed sorting method. © John Wiley & Sons, Inc. Med Res Rev, 19, No. 5, 451–462, 1999.