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Phase‐trafficking reagents and phase‐switching strategies for parallel synthesis
Author(s) -
Flynn Daniel L.
Publication year - 1999
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/(sici)1098-1128(199909)19:5<408::aid-med7>3.0.co;2-j
Subject(s) - reagent , phase (matter) , small molecule , combinatorial chemistry , solid phase synthesis , organic synthesis , molecule , nanotechnology , computer science , chemistry , materials science , catalysis , organic chemistry , biochemistry , peptide
Strategies for the parallel synthesis of small molecule arrays are reviewed with an emphasis on those approaches that integrate the sciences of organic synthesis and product purification. The use of phase‐trafficking reagents (PTRs) and phase‐switching strategies are highlighted, which allow the rapid, parallel synthesis of small molecule arrays with built‐in purification determinants. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 5, 408–431, 1999.