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The search for orally active medications through combinatorial chemistry
Author(s) -
Fecik Robert A.,
Frank Kristine E.,
Gentry Elmer J.,
Me Sanjay R.,
Mitscher Lester A.,
Telikepalli Hanumaiah
Publication year - 1998
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x
Subject(s) - bioavailability , drug , pharmacology , chemistry , absorption (acoustics) , drug discovery , combinatorial chemistry , computational biology , medicine , biochemistry , biology , materials science , composite material
The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug‐like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability. © 1998 John Wiley & Sons, Inc. Med. Res. Rev., 18, No. 3, 149–185, 1998.