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Prospects for intravascular gene therapy
Author(s) -
Smith Roy C.,
Walsh Kenneth
Publication year - 1997
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1997)12:3<140::aid-jca7>3.0.co;2-a
Subject(s) - medicine , genetic enhancement , restenosis , neovascularization , limiting , gene delivery , in vivo , gene , smooth muscle , bioinformatics , angiogenesis , cancer research , surgery , genetics , mechanical engineering , stent , engineering , biology
The goal of this review is to provide an overview of gene delivery systems and candidate genes currently being evaluated for genetic strategies in vascular gene therapy. We will discuss treatment strategies that have been shown by in vivo model systems to be efficacious in promoting neovascularization of ischemic tissue or limiting post‐interventional restenosis by inhibiting smooth muscle cell proliferation and/or encouraging re‐endothelialization. J. Clin. Apheresis 12:140–145, 1997. © 1997 Wiley‐Liss, Inc.