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Collection of platelets and peripheral progenitor cells with the Fresenius AS.TEC 204 blood cell separator
Author(s) -
Moog Rainer,
Valbonesi Mauro,
Carlier Paolo,
Müller Norbert,
Eisenbeisz Frank,
Mitschulat Heike
Publication year - 1997
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1997)12:3<126::aid-jca5>3.0.co;2-c
Subject(s) - apheresis , platelet , medicine , progenitor cell , blood cell , peripheral blood , immunology , tec , white blood cell , andrology , stem cell , surgery , biology , microbiology and biotechnology , ionosphere , physics , astronomy
The aim of the present study was to clinically evaluate the blood cell separator AS. TEC 204. One hundred fifteen platelet collections were carried out with the dual or single needle procedure. Platelet yield was 3.21 ± 0.80 × 10 11 (mean ± standard deviation) and 59.1% of the collections showed platelet counts >3.0 × 10 11 . Leukocyte contamination was 1.77 ± 2.81 × 10 6 and 89.0% of the platelet concentrates had a white blood cell content <5 × 10 6 . Using a dual needle technique with an alternating interface adjustment, all of the products were contaminated with less than 1 × 10 6 leukocytes. Furthermore, 23 peripheral progenitor cell collections were performed in 12 patients and three allogeneic donors. Median numbers of harvested CD 34 antigen expressing cells/kg body weight were 0.78 (range 0–4.7) and 3.67 × 10 6 (range 2.2–5.23), respectively. We conclude that platelet and progenitor cell collections can be carried out with efficient results. The collections were well tolerated by the donors. J. Clin. Apheresis 12:126–129, 1997. © 1997 Wiley‐Liss, Inc.