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Algorithm for managing the platelet refractory patient
Author(s) -
Slichter Sherrill J.
Publication year - 1997
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1997)12:1<4::aid-jca2>3.0.co;2-e
Subject(s) - medicine , refractory (planetary science) , platelet , intensive care medicine , immunology , astrobiology , physics
Refractoriness to platelet transfusions continues to be a major problem for many thrombocytopenic patients. A proposed algorithm for managing these patients is presented which proceeds from easily instituted changes in platelet transfusions therapy such as provision of ABO‐compatible and “fresh” platelet transfusion to the more difficult and costly process of selecting compatible platelets for patients who are documented to be alloimmunized. For non‐immunized platelet refractory recipients, multiple clinical and drug factors that may adversely effect transfusion responses have been identified. Identifying which of these factors are causally associated with poor platelet responses in any given remains a substantial challenge. J. Clin. Apheresis 12:4–9, 1997 © 1997 Wiley‐Liss, Inc.