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Reversal of acute renal allograft rejection by extracorporeal photopheresis: A case presentation and review of the literature
Author(s) -
Wolfe Jonathan T.,
Tomaszewski John E.,
Grossman Robert A.,
Gottlieb Scott L.,
Naji Ali,
Brayman Kenneth L.,
Kobrin Sydney M.,
Rook Alain H.
Publication year - 1996
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1996)11:1<36::aid-jca8>3.0.co;2-c
Subject(s) - photopheresis , extracorporeal photopheresis , medicine , apheresis , extracorporeal , transplantation , intensive care medicine , surgery , immunology , lymphoma , graft versus host disease , platelet
There is a clear need for well‐tolerated immunomodulatory agents that can aid in the prevention of acute solid organ rejection. Extracorporeal photopheresis is an apheresis‐based therapy that is currently available at many medical centers worldwide. Preliminary studies utilizing photopheresis with standard immunosuppressives have shown this therapy to successfully reverse acute cellular rejection of cardiac allografts with minimal toxicity. No formal evaluation of the role of extracorporeal photopheresis had been performed in renal transplantation. In this report, photopheresis was successfully utilized to treat acute cellular rejection in a patient with a renal allograft. This lends further support to the existing literature suggesting that photopheresis may be useful for the reversal of acute solid organ rejection. Although our experience with this patient is anecdotal, photopheresis merits further study as treatment for severe renal allograft rejection. © 1996 Wiley‐Liss, Inc.