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Anti‐DNA antibody kinetics following selective removal by adsorption using dextran sulphate cellulose columns in patients with systemic lupus erythematosus
Author(s) -
Suzuki Kimihiro,
Matsuki Yasunori,
Hidaka Toshihiko,
Ishizuka Toshiaki,
Kawakami Makoto,
Takata Satoshi,
Kutsuki Hidetoshi,
Nakamura Haruo
Publication year - 1996
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1996)11:1<16::aid-jca4>3.0.co;2-e
Subject(s) - akaike information criterion , compartment (ship) , immunoadsorption , medicine , kinetics , anti dsdna antibodies , apheresis , titer , immunology , autoantibody , antibody , platelet , statistics , oceanography , physics , mathematics , quantum mechanics , geology
The aim of this study is to determine by mathematical analysis which of two models, the one‐ or the two‐compartment model, more closely approximates the kinetics of anti‐dsDNA following immunoadsorption procedures in patients with systemic lupus erythematosus. Titers of anti‐dsDNA were measured at specified intervals after apheresis to each model by nonlinear least‐squares methods, and Akaike's Information Criterion (AIC) was calculated to determine which model most approximately described the kinetics. The A1C of the two‐compartment model was larger than that of the one‐compartment model in all 14 SLE patients (P < .001). Therefore, the one‐compartment model is thought to be suitable. The generation rate and catabolic rate of anti‐dsDNA were obtainable using this model. The anti‐dsDNA replenishment curve after an immunoadsorption session was defined by only two parameters: the generation and catabolic rates of anti‐dsDNA. © 1996 Wiley‐Liss, Inc.