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In vitro study on the removal of pemphigus antibody with immunoadsorption
Author(s) -
Yamada Hiromichi,
Takamori Kenji,
Ogawa Hideoki
Publication year - 1996
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/(sici)1098-1101(1996)11:1<14::aid-jca3>3.0.co;2-e
Subject(s) - immunoadsorption , adsorption , phenylalanine , ligand (biochemistry) , antibody , chromatography , dextran , chemistry , in vitro , medicine , apheresis , plasmapheresis , biochemistry , immunology , amino acid , organic chemistry , receptor , platelet
The adsorbability of pemphigus vulgaris (PV) antibodies to immunoadsorbent with phenylalanine, tryptophan, and dextran sulfate as ligands was examined, PV antibodies were adsorbed to immunoadsorbents with both phenylalanine and tryptophan as ligands, in batchwise adsorption and column adsorption. PV antibodies were not adsorbed to immunoadsorbent with dextran sulfate as ligand, in column adsorption. It was also shown that the rates of decrease of normal protein fractions in column adsorption with phenylalanine as a ligand were small. Our results suggest that immunoadsorption therapy using sorbent with phenylalanine as a ligand may be useful for the treatment of PV. © 1996 Wiley‐Liss, Inc.