Open AccessSynthesis and stereochemistry of ω‐azolylalkenes [1]
Author(s) -
Ding MingWu,
Xiao WenJing,
Lu ShuiMing,
Huang WenFang,
Shi DeQing,
Wu TianJie
Publication year - 1997
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/(sici)1098-1071(1997)8:2<191::aid-hc12>3.0.co;2-m
Subject(s) - wittig reaction , chemistry , alkylation , halogenation , organic chemistry , medicinal chemistry , catalysis
ω‐Azolylalkenes 3, 4, and 5 were synthesized by N‐alkylation of C‐alkylation of ω‐bromoalkenes 2, which were obtained either by phase transfer Wittig reactions of ω‐bromoalkylphosphonium salts 1 with aldehydes or by Wittig reactions of ω‐hydroxyalkylphosphonium salts 6 with aldehydes and subsequent bromination. ω‐Azolylalkenes 3 were also directly prepared by the Wittig reaction of ω‐azolylalkyltriphenylphosphonium salts 8 with aromatic aldehydes. The stereochemistry of these Wittig reactions was studied. © 1997 John Wiley & Sons, Inc.