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Differential expression of cytoskeletal proteins in the dendrites of parvalbumin‐positive interneurons versus granule cells in the adult rat dentate gyrus
Author(s) -
Ratzliff Anna de Haas,
Soltesz Ivan
Publication year - 2000
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/(sici)1098-1063(2000)10:2<162::aid-hipo5>3.0.co;2-5
Subject(s) - dentate gyrus , parvalbumin , cytoskeleton , neurofilament , neuroscience , chemistry , granule (geology) , microbiology and biotechnology , granule cell , biology , central nervous system , immunohistochemistry , cell , biochemistry , immunology , paleontology
Parvalbumin‐positive interneurons and granule cells of the dentate gyrus exhibit characteristic differences in morphological, cytochemical, physiological, and pathophysiological properties. Several of these defining features, including dendritic morphology, spine density, and sensitivity to insults, are likely to be influenced by the neuronal cytoskeleton. The data in this paper demonstrate striking differences in the expression levels of all three neurofilament triplet proteins, as well as α‐internexin and β‐tubulin III, between the parvalbumin‐positive interneurons and dentate granule cells. Therefore, the molecular composition of intermediate filaments and microtubules in the dendritic domain of parvalbumin‐positive dentate interneurons is distinct from the cytoskeleton of neighboring granule cells, indicating the existence of highly cell type‐specific cytoskeletal architecture within the dentate gyrus. Hippocampus 2:162–168, 2000 © 2000 Wiley‐Liss, Inc.