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Effects of radiofrequency versus neurotoxic cingulate lesions on spatial reversal learning in mice
Author(s) -
Meunier Martine,
Destrade Claude
Publication year - 1997
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/(sici)1098-1063(1997)7:4<355::aid-hipo1>3.0.co;2-i
Subject(s) - ibotenic acid , cingulate cortex , neuroscience , anterior cingulate cortex , lesion , cingulum (brain) , hippocampus , psychology , posterior cingulate , hippocampal formation , cortex (anatomy) , magnetic resonance imaging , central nervous system , medicine , cognition , radiology , white matter , psychiatry , fractional anisotropy
Mice with radiofrequency (RF) lesions of the posterior (PC) or anterior (AC) cingulate cortex were trained on spatial discrimination reversal learning in a T‐maze. The results were compared with those obtained in an earlier study after ibotenic acid (IBO) cingulate lesions. PC‐RF lesions facilitated the initial discrimination and first reversal, whereas they retarded subsequent reversals; in contrast, PC‐IBO lesions yielded a deficit on the initial discrimination and first reversal, but had no effect on subsequent reversals. AC‐IBO, but not AC‐RF lesions, precluded the formation of a learning set across reversals. These data suggest that cingulum transection, which accompanies RF but not IBO lesions, can mask or even antagonize the specific effects of cingulate damage. Consequently, inferences made from the effects of conventional lesions to assess and distinguish the functions of the two cingulate areas appear subject to caution. Hippocampus 7:355–360, 1997. © 1997 Wiley‐Liss, Inc.