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Dendritic calcium channels and hippocampal long‐term depression
Author(s) -
Christie Brian R.,
Magee Jeffrey C.,
Johnston Daniel
Publication year - 1996
Publication title -
hippocampus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 155
eISSN - 1098-1063
pISSN - 1050-9631
DOI - 10.1002/(sici)1098-1063(1996)6:1<17::aid-hipo4>3.0.co;2-4
Subject(s) - neuroscience , hippocampal formation , term (time) , chemistry , psychology , depression (economics) , physics , quantum mechanics , economics , macroeconomics
The authors examine the potential role of the different sources of dendritic Ca 2+ influx in long‐term depression (LTD) of synaptic efficacy. Recent data on the location and functional distribution of voltage‐gated Ca 2+ channels obtained from fluorescence imaging and patch clamp experiments are presented. This is followed by a discussion of the existing evidence for different sources of Ca 2+ playing a role in the induction of LTD. The authors conclude that a number of key issues need to be resolved before any conclusions are drawn as to the involvement of any specific route of Ca 2+ entry in LTD. © 1996 Wiley‐Liss, Inc.