Open AccessClinical utility of CA125 levels in predicting laparoscopically confirmed salpingitis in patients with clinically diagnosed pelvic inflammatory disease
Author(s) -
Moore E.,
Soper D.E.
Publication year - 1998
Publication title -
infectious diseases in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.656
H-Index - 48
eISSN - 1098-0997
pISSN - 1064-7449
DOI - 10.1002/(sici)1098-0997(1998)6:4<182::aid-idog8>3.0.co;2-t
Subject(s) - salpingitis , medicine , pelvic inflammatory disease , laparoscopy , disease , surgery
Objective The purpose of this study was to determine the utility of serum CA125 determinations in diagnosing acute salpingitis. Methods CA125 levels were determined for 34 women with the clinical diagnosis of pelvic inflammatory disease (PID). Acute salpingitis was confirmed laparoscopically in 28 women (82.3%). Results Twenty patients (71.4%) with laparoscopically confirmed acute salpingitis had CA125 levels greater than 7.5 units, compared with no patients (0/6) with laparoscopically normal tubes ( P = 0.002). The degree of elevation of CA125 levels correlated with the severity of tubal inflammation noted at laparoscopy. All patients with levels above 16 units had laparoscopically severe salpingitis. Conclusions We conclude that while CA125 levels above 7.5 units may modestly improve the ability of the clinical diagnosis of PID to accurately reflect visually confirmed acute salpingitis, limitations of the test make its clinical utility questionable. Infect. Dis. Obstet. Gynecol. 6:182–185, 1998. © 1998 Wiley‐Liss, Inc.