Open AccessCell damage at the origin of antiphospholipid antibodies and their pathogenic potential in recurrent pregnancy loss
Author(s) -
Piroux Véronique,
Eschwège Valérie,
Freyssinet JeanMarie
Publication year - 1997
Publication title -
infectious diseases in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.656
H-Index - 48
eISSN - 1098-0997
pISSN - 1064-7449
DOI - 10.1002/(sici)1098-0997(1997)5:2<176::aid-idog13>3.0.co;2-l
Subject(s) - pregnancy , immunology , antibody , antiphospholipid syndrome , thrombosis , medicine , antigen , biology , genetics
Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss. Infec. Dis. Obstet. Gynecol. 5:176–180, 1997. © 1997 Wiley‐Liss, Inc.