Open AccessHuman immunodeficiency virus‐associated nephropathy in pregnancy
Author(s) -
Eriksen Nancy L.,
Mastrobattista Joan M.
Publication year - 1996
Publication title -
infectious diseases in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.656
H-Index - 48
eISSN - 1098-0997
pISSN - 1064-7449
DOI - 10.1002/(sici)1098-0997(1996)4:2<89::aid-idog8>3.0.co;2-2
Subject(s) - medicine , gestation , nephropathy , hemodialysis , dialysis , pregnancy , creatinine , zidovudine , kidney disease , renal function , anemia , urinary system , obstetrics , surgery , endocrinology , human immunodeficiency virus (hiv) , immunology , viral disease , diabetes mellitus , biology , genetics
Background Human immunodeficiency virus (HIV)‐associated nephropathy typically leads to end‐stage renal disease requiring dialysis within 3–4 months. This report describes the prenatal course of a patient with HIV‐associated nephropathy requiring dialysis during pregnancy. Purpose A 23‐year‐old nulliparous, black female presented at 13 weeks gestation with a history of HIV‐associated nephropathy and anemia. She had a CD4 count of 350/mm 3 , a total urinary protein of 1.7 g/day, and a serum creatinine of 4.8 mg/dl. The patient was begun on zidovudine, 500 mg daily, and erythropoietin, 4,000 units weekly. At 23 weeks gestation, when she developed hypertension, a total urinary protein of 3.4 g/day, and a serum creatinine of 4.4 mg/dl, she was hospitalized. Her renal function continued to deteriorate, requiring hemodialysis. At 29‐4/7 weeks, she developed preterm labor, for which she was placed on indomethacin. Four days later, at 30 weeks gestation, she delivered a viable male infant. Conclusion HIV‐associated nephropathy during pregnancy can be successfully managed with hemodialysis. © 1996 Wiley‐Liss, Inc.