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Enantioselective Esterification of Racemic Ibuprofen in Solvent Media under Reduced Pressure
Author(s) -
Roure Frédéric,
Ducret Amélie,
Trani Michael,
Lortie Robert
Publication year - 1997
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/(sici)1097-4660(199706)69:2<266::aid-jctb698>3.0.co;2-6
Subject(s) - enantioselective synthesis , solvent , chemistry , organic chemistry , lipase , ibuprofen , solvent effects , catalysis , enzyme , biology , pharmacology
The enantioselective esterification of ( R , S )‐ibuprofen has been performed with Novozym 435 TM in solvent media under reduced pressure. The nature of the solvent affects the activity and enantioselectivity of the lipase. High esterification rates are obtained in solvents having high hydrophobicity (log P >4). On the other hand, the best enantioselectivity is obtained with solvents having low hydrophobicity (log P <3). This particular enantioselectivity trend is observed within the individual solvent families investigated (alkanes, ethers and aromatics). © Canadian Crown Copyright 1997