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Syntheses and insecticidal activities of novel 2,5‐disubstituted‐1,3,4‐oxadiazoles
Author(s) -
Qian Xuhong,
Zhang Rong
Publication year - 1996
Publication title -
journal of chemical technology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 117
eISSN - 1097-4660
pISSN - 0268-2575
DOI - 10.1002/(sici)1097-4660(199610)67:2<124::aid-jctb528>3.0.co;2-g
Subject(s) - nitrile , chemistry , stereochemistry , combinatorial chemistry , organic chemistry
A series of novel symmetrical and asymmetrical 2,5‐disubstituted‐1,3,4‐oxadiazoles and their intermediates were synthesized. A convenient procedure for preparation of aromatic nitrile and ester intermediates is reported. The insecticidal activities of oxadiazoles against Dropsophila melanogaster were recorded, and analysis of structure–activity relationships showed that the highest occupied molecular orbital energy ( E H ) was the main factor to affect the bioactivities.