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nm23 : Unraveling its biological function in cell differentiation
Author(s) -
Lombardi Daniela,
Lacombe MarieLise,
Paggi Marco G.
Publication year - 2000
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/(sici)1097-4652(200002)182:2<144::aid-jcp2>3.0.co;2-6
Subject(s) - biology , suppressor , cellular differentiation , phenotype , gene , function (biology) , cell , microbiology and biotechnology , cell growth , cell cycle , genetics
Tumor suppressor genes have a pivotal role in normal cells regulating cell cycle processes negatively. Furthermore, the inhibition of cell proliferation is a crucial step in the achievement of cell differentiation. Increasing evidence suggests that the nm23 genes, initially documented as suppressors of the invasive phenotype in some cancer types, are involved in the control of normal development and differentiation. In this review, we summarize some data concerning the involvement of the nm23 genes in development and differentiation, attempting to delineate an overall view of many facets of their biological role. J. Cell. Physiol. 182:144–149, 2000. © 2000 Wiley‐Liss, Inc.