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Modes of regulation of ubiquitin‐mediated protein degradation
Author(s) -
Kornitzer Daniel,
Ciechanover Aaron
Publication year - 2000
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/(sici)1097-4652(200001)182:1<1::aid-jcp1>3.0.co;2-v
Subject(s) - ubiquitin , proteasome , protein degradation , microbiology and biotechnology , signal transduction , degradation (telecommunications) , ubiquitin ligase , ubiquitin conjugating enzyme , biology , chemistry , biochemistry , gene , computer science , telecommunications
The ubiquitin‐proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin‐mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin‐mediated degradation can be modulated by physiological signals. J. Cell. Physiol. 182:1–11, 2000. © 2000 Wiley‐Liss, Inc.