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POU family transcription factors in the nervous system
Author(s) -
Latchman David S.
Publication year - 1999
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/(sici)1097-4652(199905)179:2<126::aid-jcp2>3.0.co;2-m
Subject(s) - pou domain , biology , transcription factor , nervous system , transcription (linguistics) , genetics , computational biology , gene , neuroscience , homeobox , linguistics , philosophy
The POU (Pit‐Oct‐Unc) family of transcription factors was originally defined on the basis of a common DNA binding domain in the mammalian factors Pit‐1, Oct‐1, and Oct‐2 as well as the nematode protein Unc‐86. Subsequently, a number of other POU family factors have been identified in both vertebrates and invertebrates. Many of these original and subsequently isolated members of the family have been shown to play critical roles in the development and functioning of the nervous system. To exemplify this, studies are described involving the functional characterisation of the Oct‐2 factor, one of the original POU factors, and of the Brn‐3 factors, which were isolated subsequently and are the mammalian factors most closely related to Unc‐86. J. Cell. Physiol. 179:126–133, 1999. © 1999 Wiley‐Liss, Inc.