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Signal transduction pathways in the mitogenic response to G protein–coupled neuropeptide receptor agonists
Author(s) -
Rozengurt Enrique
Publication year - 1998
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/(sici)1097-4652(199812)177:4<507::aid-jcp2>3.0.co;2-k
Subject(s) - signal transduction , g protein coupled receptor , microbiology and biotechnology , tyrosine phosphorylation , biology , phosphorylation , bombesin , second messenger system , signal transducing adaptor protein , grb2 , gq alpha subunit , receptor , neuropeptide , biochemistry
Neuropeptides, including mammalian bombesin‐like peptides, act as potent cellular growth factors and have been implicated in a variety of normal and abnormal processes, including development, inflammation, and malignant transformation. These signaling peptides exert their characteristic effects on cellular processes by binding to specific G protein–coupled receptors (GPCR) on the surface of their target cells. Typically, the binding of a neuropeptide to its cognate GPCR triggers the activation of multiple signal transduction pathways that act in a synergistic and combinatorial fashion to relay the mitogenic signal to the nucleus and promote cell proliferation. A rapid increase in the synthesis of lipid‐derived second messengers with subsequent activation of protein phosphorylation cascades is an important early response to neuropeptides. An emerging theme in signal transduction is that these agonists also induce rapid and coordinate tyrosine phosphorylation of cellular proteins including the nonreceptor tyrosine kinase p125 fak and the adaptor proteins p130 cas and paxillin. This tyrosine phosphorylation pathway depends on the integrity of the actin cytoskeleton and requires functional Rho. The purpose of this article is to review recent advances in unraveling the pathways that play a role in transducing mitogenic and migratory responses induced by G protein–coupled neuropeptide receptor agonists. J Cell Physiol 177:507–517, 1998. © 1998 Wiley‐Liss, Inc.