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Differentiation commitment in normal hemopoiesis and leukemic transformation
Author(s) -
Metcalf D.,
Nicola N. A.,
Robb L.
Publication year - 1997
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/(sici)1097-4652(199711)173:2<131::aid-jcp9>3.0.co;2-o
Subject(s) - haematopoiesis , abnormality , transformation (genetics) , biology , population , microbiology and biotechnology , immunology , psychology , genetics , stem cell , social psychology , sociology , demography , gene
Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.