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Recruitment of chromatin remodeling machines
Author(s) -
Peterson Craig L.,
Logie Colin
Publication year - 2000
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(20000801)78:2<179::aid-jcb1>3.0.co;2-e
Subject(s) - chromatin remodeling , chromatin , biology , histone modifying enzymes , histone , microbiology and biotechnology , chia pet , nucleosome , scaffold/matrix attachment region , dna replication , genetics , dna , computational biology
The assembly of eukaryotic DNA into folded nucleosomal arrays has drastic consequences for many nuclear processes that require access to the DNA sequence, including RNA transcription, DNA replication, recombination, and repair. Two types of highly conserved chromatin remodeling enzymes have been implicated as regulators of the repressive nature of chromatin structure: ATP‐dependent remodeling complexes and nuclear histone acetyltransferases (HATs). Recent studies indicate that both types of enzymes can be recruited to chromosomal loci through either physical interactions with transcriptional activators or via the global accessibility of chromatin during S phase of the cell cycle. Here we review these recent observations and discuss the implications for gene‐specific regulation by chromatin remodeling machines. J. Cell. Biochem. 78:179–185, 2000. © 2000 Wiley‐Liss, Inc.