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Vimentin expression in human squamous carcinoma cells: Relationship with phenotypic changes and cadherin‐based cell adhesion
Author(s) -
Islam Shahidul,
Kim JaeBeom,
Trendel Jill,
Wheelock Margaret J.,
Johnson Keith R.
Publication year - 2000
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(20000701)78:1<141::aid-jcb13>3.0.co;2-r
Subject(s) - vimentin , epithelial–mesenchymal transition , cadherin , phenotype , mesenchymal stem cell , transition (genetics) , pathology , biology , microbiology and biotechnology , cancer research , cell , immunohistochemistry , immunology , medicine , gene , genetics
Phenotypic changes resembling an epithelial‐to‐mesenchymal transition often occur as epithelial cells become tumorigenic. Two proteins that have been implicated in this process are vimentin and N‐cadherin. In this study, we sought to establish a link between expression of vimentin and N‐cadherin as oral squamous epithelial cells undergo a morphologic change resembling an epithelial‐to‐mesenchymal transition. We found that N‐cadherin and vimentin did not influence the expression of one another. J. Cell. Biochem. 78:141–150, 2000. © 2000 Wiley‐Liss, Inc.