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Differentiation and apoptosis of neuroblastoma cells: Role of N‐myc gene product
Author(s) -
Galderisi Umberto,
Di Bernardo Giovanni,
Cipollaro Marilena,
Peluso Gianfranco,
Cascino Antonino,
Cotrufo Roberto,
Melone Mariarosa A.B.
Publication year - 1999
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(19990401)73:1<97::aid-jcb11>3.0.co;2-m
Subject(s) - apoptosis , neuroblastoma , gene , gene product , biology , cellular differentiation , microbiology and biotechnology , n myc , gene expression , cell growth , cancer research , cell , cell culture , genetics , ganglioneuroma
To clarify the role and function of the N‐myc product in cell differentiation and apoptosis, we used the antisense oligonucleotide technique to inhibit N‐myc gene expression in neuroblastoma cells with different phenotypes: intermediate (I) and neuronal (N), or Schwann‐glia (S), respectively. The results suggest that N‐myc operates along different pathways. Inhibiting N‐myc gene expression either results in suppression of cell proliferation or in induction of differentiation and/or apoptosis. J. Cell. Biochem. 73:97–105, 1999. © 1999 Wiley‐Liss, Inc.