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Nuclear neighbours: The spatial and functional organization of genes and nuclear domains
Author(s) -
Schul Wouter,
de Jong Luitzen,
van Driel Roel
Publication year - 1998
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(19980801)70:2<159::aid-jcb2>3.0.co;2-n
Subject(s) - functional organization , gene , nuclear gene , spatial organization , computational biology , biology , evolutionary biology , genetics , neuroscience , genome
It is becoming clear that the cell nucleus is not only organized in domains but that these domains are also organized relative to each other and to the genome. Specific nuclear domains, enriched in different proteins and RNAs, are often found next to each other and next to specific gene loci. Several lines of investigation suggest that nuclear domains are involved in facilitating or regulating gene expression. The emerging view is that the spatial relationship between different domains and genes on different chromosomes, as found in the nucleolus, is a common organizational principle in the nucleus, to allow an efficient and controlled synthesis and processing of a range of gene transcripts. J. Cell. Biochem. 70:159–171. © 1998 Wiley‐Liss, Inc.