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The haemochromatosis candidate gene HFE (HLA‐H) of man and mouse is located in syntenic regions within the histone gene cluster
Author(s) -
Albig Werner,
Drabent Birgit,
Burmester Nicole,
Bode Christa,
Doenecke Detlef
Publication year - 1998
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(19980501)69:2<117::aid-jcb3>3.0.co;2-v
Subject(s) - gene cluster , gene , biology , genetics , complementary dna , microbiology and biotechnology , synteny , histone , gene map , chromosome , pair rule gene , gene mapping , gene expression , regulator gene
The HFE (HLA‐H) gene is a strong candidate gene for hereditary haemochromatosis and was localized on the short arm of chromosome 6 to 6p21.3‐p22. In addition, the sequence of the homologous mouse and rat cDNA and a partial sequence from the mouse gene have been reported recently. In this report, we describe the location of the human and the mouse HFE (HLA‐H) gene within the histone gene clusters on the human chromosome 6 and the mouse chromosome 13. Both the human and the murine gene were located on syntenic regions within the histone gene clusters in the vicinity of the histone H1t gene. The genomic sequence of the human HFE (HLA‐H) gene and the 3′ portion of the homologous mouse gene were determined. Comparison of the genomic sequences from man and mouse and the cDNA sequence from rat shows significant similarities, also beyond the transcribed region of the mouse gene. J. Cell. Biochem. 69:117–126, 1998. © 1998 Wiley‐Liss, Inc.