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Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation
Author(s) -
Lian Jane B.,
Stein Gary S.,
Stein Janet L.,
van Wijnen André J.
Publication year - 1998
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(1998)72:30/31+<62::aid-jcb10>3.0.co;2-s
Subject(s) - osteocalcin , transactivation , osteoblast , homeobox , transcription factor , microbiology and biotechnology , biology , gene , runx2 , promoter , phenotype , regulation of gene expression , gene expression , transcriptional regulation , genetics , alkaline phosphatase , in vitro , biochemistry , enzyme
The bone tissue‐specific osteocalcin gene remains one of a few genes that exhibits osteoblast‐restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the osteoblast phenotype. In this review, we have focused on emerging concepts related to molecular mechanisms supporting osteoblast growth and differentiation based on the discoveries that the osteocalcin gene is regulated by homeodomain factors, AP‐1 related proteins, and the bone restricted Cbfa1/AML3 transcription factor. J. Cell. Biochem. Suppls. 30/31:62–72, 1998. © 1998 Wiley‐Liss, Inc.