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DNA vaccines: Vector design, delivery, and antigen presentation
Author(s) -
Feltquate David M.
Publication year - 1998
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(1998)72:30/31+<304::aid-jcb37>3.0.co;2-w
Subject(s) - dna vaccination , vector (molecular biology) , immune system , transfection , plasmid , antigen , antigen presentation , virology , biology , dna , immunology , computational biology , immunization , t cell , recombinant dna , gene , genetics
Inoculations with antigen‐expressing plasmid DNAs (DNA vaccines) in the production of protective immune responses. Since the initial development of DNA vaccines more than 5 years ago, major strides have been made in the design of efficient vaccine vectors and in the process of vaccine delivery. However, many questions remain regarding the mechanism of cellular transfection and in the development of immune responses. This review addresses functional aspects of DNA vaccines, including vector design and delivery, as well as cellular transfection and antigen presentation. J. Cell. Biochem. Suppls. 30/31:304–311, 1998. © 1998 Wiley‐Liss, Inc.