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Steroid receptors at the nexus of transcriptional regulation
Author(s) -
Barrett Thomas J.,
Spelsberg Thomas C.
Publication year - 1998
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(1998)72:30/31+<185::aid-jcb23>3.0.co;2-m
Subject(s) - nuclear receptor , pelp 1 , nuclear receptor co repressor 1 , receptor , nuclear receptor coactivator 1 , microbiology and biotechnology , estrogen related receptor gamma , transcription factor , steroid hormone , biology , hormone receptor , steroid hormone receptor , chromatin , hormone , biochemistry , genetics , estrogen receptor , gene , cancer , breast cancer
During the past few years, our understanding of nuclear receptor action has dramatically improved as a result of the identification and functional analysis of co‐regulators such as factors involved in chromatin remodeling, transcription intermediary factors (co‐repressors and co‐activators), and direct interactions with the basal transcriptional machinery. Furthermore, the elucidation of the crystal structures of the empty ligand‐binding domains of the nuclear receptor and of complexes formed by the nuclear receptor's ligand‐binding domain bound to agonists and antagonists has contributed significantly to our understanding of the early events of nuclear receptor action. However, the picture of hormone‐ and hormone receptor‐mediated mechanisms of gene regulation remain incomplete and extremely complicated when one also considers the “nontraditional” interactions of hormone‐activated nuclear receptors, for example, interactions between the activated steroid receptors and components of the chromatin/nuclear matrix; and finally the nongenomic effects that steroid hormones can exhibit with other signaling pathways. In this prospectus on steroid receptors, we discuss the implications of various steroid hormone and nuclear receptor interactions and potential future directions of investigation. J. Cell. Biochem. Suppls. 30/31:185–193, 1998. © 1999 Wiley‐Liss, Inc.